There are several factors that make PRF (platelet-rich fibrin) the superior treatment option over PRP (platlet-rich plasma).While both treatments require some blood to be drawn , PRP requires more blood than PRF. When it comes to processing the blood sample, the lower spin speed of a PRF treatment allows for more white blood cells, stem cells and platelets to remain in the plasma layer which which is collected for treatment. This provides more healing factors in PRF than is typical in a PRP treatment. Lastly, the lower spin speed results in less trauma to the individual cells in your blood so more stem cells remain in tact in the final PRF product.
A higher concentration of platelets
Notable too is that PRF samples typically contain on average 2-3x the level of platelets as PRP samples. The latest literature shows that higher concentrations of platelets result in more effective treatment.
No need for anticoagulants
Unlike with PRP, when preparing PRF, no anticoagulants (like acid citrate dextrose or ACD) are needed to process the blood sample. Without the presence of anticoagulants, the fibrinogen in your blood is converted to fibrin by thrombin after application, this creates a spongy fibrin matrix that naturally activates the platelets in your skin and results in the optimum conditions for the slow release of growth factors.